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We've already created a US version that you can watch here for reference: https://youtu.be/VFMIh04KQ7w 2016-08-25 21:41:15 GMT 2016-08-30 15:00:00 (GMT -07:00) Mountain Time (US & Canada) Yes (click here to learn more about ) Closed 8 8 0 direct invitation(s) have been sent by the voice seeker resulting in 0 audition(s) and/or proposal(s) so far. Voice123 SmartCast is seeking 20 auditions and/or proposals for this project (approx.) Invitations sent by SmartCast have resulted in 8 audition(s) and/or proposal(s) so far.
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Haemophilia treatment has come a long way from on-demand to the current standard of care, prophylaxis.
To reduce the risk of bleeding, physicians often consider a prophylactic regimen for some of their patients in order to keep their Factor VIII levels above a certain minimum level.
However, the ultimate goal is helping all patients reach zero bleeds.
When factor VIII is infused, initially the entire dose enters the bloodstream, but is then used or removed by the body over time.
Typically, haemophilia A patients on prophylaxis infuse 2-4 times per week…
...without knowing how fast their FVIII levels are decreasing.
The study of what happens to medicines, such as Factor VIII, from when they enter the body until they leave is called Pharmacokinetics, or PK for short.
It comes from the Ancient Greek words that mean “drugs in motion.”
Let’s take a closer look at PK.
Your pK is like your own personal roller coaster track.
Shortly after an infusion the ‘peak’ factor level is reached – this is the highest level of Factor VIII in the body.
Over time, the amount of Factor VIII in the body is reduced as it is used and removed.
“Half life” is the length of time it takes for the Factor VIII level in the body to decrease by half.
The Factor VIII level continues to drop, ultimately reaching its lowest point just prior to the next infusion – this is called the ‘trough’.
As patients reach this trough, they can be at increased risk of bleeding.
Patients treated with recombinant FVIII have demonstrated significant variability in their pK profiles,
...so how do you know when your PK profile puts you at a greater risk for a bleed?
Since patients may process recombinant FVIII at different rates…
…it may take one patient with severe haemophilia longer before they reach the level at which their bleeding risk is increased…
… compared to another patient with haemophilia who may reach the same trough level sooner.
Therefore understanding your pK profile is a critical component of haemophilia care and helps explain why different patients respond differently to treatments
Knowing your pK profile enables your physician to personalise your treatment along with other key considerations such as age, joint health, bleeding history, adherence and physical activity.
Every individual with haemophilia is different. Understanding these differences and personalizing care are key elements to help put every patient on the right track towards minimizing the burden of the disease in the treatment of haemophilia.
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