Multiple Sclerosis VO ZD1078391
Medical narration for a physician audience. To be played at a conference and then will sit on the company's website for educational purposes. This is a buyout. This is non-broadcast. The entire script is only about 4 minutes and 35 seconds long. We would need to connect via ISDN, Source Connect or ipDTL, from your home studio.
2016-07-28 21:42:45 GMT
2016-07-28 17:38:06 (GMT -05:00) Eastern Time (US & Canada)
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Closed - Note: This project was manually closed by the voice seeker before it reached its original deadline.
220 direct invitation(s) have been sent by the voice seeker resulting in 0 audition(s) and/or proposal(s) so far.
Voice123 SmartCast is seeking 20 auditions and/or proposals for this project (approx.) Invitations sent by SmartCast have resulted in 2 audition(s) and/or proposal(s) so far.
The Voice Actor should be located in:
Fixed - USD 500
Training, business presentations, sales, and web sites
There are no special pre-, post-, or production requirements for this project.
This is a non-union project
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the brain and spinal cord that is a common cause of serious physical disability.
Central nervous system (CNS) lesions are a hallmark of MS and are caused by immune-cell infiltration across the blood-brain barrier that promotes inflammation, demyelination, gliosis, and neuroaxonal degeneration, leading to disruption of neuronal signaling.
Initially, autoreactive CD4+ T helper cells are activated in the periphery.
Activated CD4+ T-cells increase the immune response by recruiting additional immune cells including: CD8+ cells, B-cells, granulocytes, monocytes, and mast cells.
These cells adhere to and then cross the blood-brain barrier endothelium.
In order to do so, activated cells produce pro-inflammatory cytokines (TNF-α and IFN-gamma), which activate adhesion molecules (LFA-1 and VLA-4) on the blood-brain endothelium.
Following entry into the CNS, CD4+ T-cells are reactivated by antigen-presenting cells.
Please note that you should only use the script or your recording of it for auditioning purposes. The script is property, unless otherwise specified, of the voice seeker and it is protected by international copyright laws.
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