Scientific VO

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Project Main Details

Scientific VO 
Looking for scientific, conversational, corporate and informative sounding voices. Possibly a few British sounding voices but it is not required. Studio is located in Philadelphia, however ISDN is also acceptable. 
2014-07-12 13:26:48 GMT
2014-07-15 13:00:00 (GMT -05:00) Eastern Time (US & Canada) 
Yes (click here to learn more about Voice123's SmartCast)
0 direct invitation(s) have been sent by the voice seeker resulting in 0 audition(s) and/or proposal(s) so far.
Voice123 SmartCast is seeking 25 auditions and/or proposals for this project (approx.) Invitations sent by SmartCast have resulted in 10 audition(s) and/or proposal(s) so far.

Project Parameters

The Voice Actor should be located in:
Student or Non-for-profit student project - USD 350
Training, business presentations, sales, and web sites
6 Minutes
English - British OR English - USA and Canada
Middle Age Female OR Middle Age Male
• Talent must record at a designated studio in a specified area OR
There are no special pre-, post-, or production requirements for this project.
Not defined
This is a non-union project

Script Details

***Please submit a custom demo*** 
Below is a link to the video for pronunciation of words, note, the scratch track in the video is an older version of the script.
password: moa

Be sure to do TWO takes on the same MP3.

Coagulation ********** plays a pivotal role in the final common pathway of the coagulation cascade.********** assembles together with Factor Va on the platelet surface, forming the prothrombinase complex, which is responsible for the large-scale conversion of prothrombin to thrombin.

Inhibitors of ********* work by one of two distinct mechanisms. Small molecule direct factor Xa inhibitors, such as apixaban or rivaroxaban, bind to the active site of ********* and neutralize the catalytic activity of the prothrombinase complex. Indirect **********inhibitors, such as enoxaparin or fondaparinux, bind to native Antithrombin III and potentiate its capacity to inhibit *********.

Andexanet, an investigational drug, is a recombinant **************** derivative being developed for use as a universal antidote to direct and indirect ********* inhibitors. ********* lacks the membrane binding domain of plasma-derived ********, and does not compete against native ********* in prothrombinase assembly on the platelet surface. ********* also features a serine to alanine substitution in the active site, and a deletion of the heavy chain activating peptide that is present in native ********; thus, ********* lacks pro- or anticoagulant activity on its own.

The mechanism of action of ********* is based on its capacity to function as a decoy ********* molecule. ********* binds to direct **********inhibitors with high affinity, sequestering the inhibitor, and thus rapidly reducing the free plasma concentration and neutralizing the anticoagulant effect of the inhibitor. ********* also binds to and sequesters molecules of **************** that are complexed with indirect inhibitor molecules, disrupting the capacity of ************ complex to bind tonative *********. Currently there is no effective antidote for reversal of ********* inhibitors, especially the direct ********* inhibitors, the uptake of which is increasing. 
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