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2014-03-14 21:53:54 GMT 2014-03-18 20:00:00 (GMT -05:00) Eastern Time (US & Canada) Yes (click here to learn more about ) Closed 25 25 0 direct invitation(s) have been sent by the voice seeker resulting in 0 audition(s) and/or proposal(s) so far. Voice123 SmartCast is seeking 25 auditions and/or proposals for this project (approx.) Invitations sent by SmartCast have resulted in 25 audition(s) and/or proposal(s) so far.
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Ambrx brings that same targeted and thoughtful design to biologic medicines, using a breakthrough technology by expanding the human genome.
It starts with antibodies, our natural weapons against invasion from foreign substances. With exquisite selectivity, antibodies recognize and bind to these proteins, tagging them for removal or destruction by the immune system.
We can use this to our advantage to target specific cell types that are present in disease. A healthy cell will express a few of the same receptors on its surface. But in a disease such as cancer, tumor cells express a larger number of the same disease-related receptors on the surface, offering unique targets for specific recognition by antibodies.
Antibody drug conjugates expand our medical arsenal by linking a potent drug to the antibody, resulting in an antibody-drug combination that can seek out and selectively deliver toxin to kill diseased cells, leaving healthy cells intact.
There are a variety of ways to attach the drug molecule to the antibody. In conventional methods, two of the 20 amino acids that comprise the building blocks of all proteins, lysine and cysteine, are commonly used as linkers to hook the drug to the antibody. However, because lysine and cysteine are distributed throughout proteins, the drug could attach at multiple locations along the antibody.
Ambrx overcame this challenge through the creation of a 21st amino acid . . . a fundamental advance in genomic medicine for the 21st century.
That novel amino acid can be inserted into precise preselected locations on the antibody . . .
And linked to a precise number of toxin molecules.
With conventional methods, some of the antibodies carry no drug at all . . . effectively blocking the binding of antibodies carrying the needed drug.
And other antibodies may carry as many as eight drug molecules, which can be too toxic, and can result in the antibody falling apart, releasing the toxin into the blood stream, and potentially damaging healthy tissue.
Ambrx can optimize antibody drug conjugates, unleashing their full potential through highly controlled linkage technology . . . effectively widening the therapeutic window to provide patients more effective treatments with less toxicity.
The Ambrx technology revolutionizes medicine with site-specific conjugation and allows for precise design and optimization of biotherapeutics.
Some will call the Ambrx approach “game changing,” but life-threatening diseases are not games. The war against cancer and disease begins and ends with the patient, and our goal is to deliver safer and more effective medications using the Ambrx technology.
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